>gfortran -static -O3 -ffast-math -lm -o TMscore TMscore.f Such as Mac, which does not support static build): (you can ignore the '-static' option for some machines, You can compile the program in your Linux computer by
To download the newest version of the TM-score source code Input Email: (optional, where results will be sent to).Merge all chains and compare them as monomers). These are complex structures (server will Input Structure 2, Experimental structure in PDB format (mandatory):.Please copy and paste your structure file here. TM-score on-line ( view an example of output)
Higher than 0.5 assume generally the same fold in SCOP/CATH. Scores below 0.17 correspond to randomly chosen unrelated proteins whereas structures with a score TM-score has the value in (0,1], where 1 indicates a perfect match between two structures.įollowing strict statistics of structures in the PDB, (2) TM-score introduces a length-dependent scale to normalize theĭistance errors and makes the magnitude of TM-score length-independent Similarity than to the local structural variations (1) TM-score weights smaller distance errors stronger than larger distanceĮrrors and makes the score value more sensitive to the global fold It is designed to solve two major problems in traditional metrics such as TM-score is a metric for assessing the topological similarity of protein structures.